Coenzyme Q10 - Effective Migraine Preventive?

Drug therapy for migraine has made improvements in recent years; however, the emphasis has been on treatment of an existing migraine rather than prevention. Another issue for individuals with migraines is that prescription migraine drugs are not without side effects.

Increasing interest into the possible role of mitochondrial dysfunction in migraine has led some researchers to attempt to correct this malfunction using coenzyme Q10, the ubiquitous mitochondrial cofactor. A recent double-blind, placebo-controlled trial of coenzyme Q10 in 42 migraine patients found 100 mg three times daily significantly reduced the incidence of migraine (defined as a drop in incidence of 50 percent) in almost 50 percent of patients, compared to 14 percent of patients given placebo. A previous open-label study found 150 mg coQ10 per day resulted in a greater-than-50-percent decreased incidence in 61 percent of patients.

Many patients with migraines are searching for alternatives to drugs such as Depakote (an anti-seizure medication now given to prevent migraines) to help prevent migraine attacks. It appears coenzyme Q10 may be a viable alternative to the side-effect-prone prescriptions for this debilitating condition.

The Role of Coenzyme Q10 in Clinical Medicine: Part I. Altern Med Rev 1996;1(1)
The Role of Coenzyme Q10 in Clinical Medicine: Part II. Cardiovascular Disease, Hypertension, Diabetes Mellitus, and Infertility. Altern Med Rev 1996;1(3)